Journal
JOURNAL OF IMMUNOLOGY
Volume 176, Issue 6, Pages 3315-3319Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.176.6.3315
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- NIAID NIH HHS [1R01 AI 053146, R21 AI 051386] Funding Source: Medline
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The action of type I IFN (IFN-I) on APCs is well studied, but their direct effect on CD4 T cells is unclear. To address this, we transferred IFN-I receptor-deficient (IFN-IR0) and -sufficient (wild-type, WT) TCR-transgenic CD4 T cells into WT mice and analyzed their response to immunization. In response to lymphocytic choriomeningitis virus immunization, WT CD4 T cells expanded similar to 100-fold, whereas IFN-IR0 CD4 T cells expanded < 10-fold. However, both WIT and IFN-IR0 CD4 T cells expanded similar to 10-fold after Listeria monocytogenes immunization. Poor expansion of IFN-IR0 CD4 T cells after lymphocytic choriomeningitis virus immunization was not due to a defect in proliferation or initial activation but to poor survival of the daughter cells. Thus, direct IFN-I signals can play either a critical or minimal role in CD4 T cell clonal expansion depending on the specific pathogen.
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