Journal
IMMUNOLOGY OF DIABETES V: FROM BENCH TO BEDSIDE
Volume 1150, Issue -, Pages 46-53Publisher
WILEY-BLACKWELL
DOI: 10.1196/annals.1447.009
Keywords
humanized mouse; diabetes; beta cell function
Funding
- National Institutes of Health [AI46629, DK53006]
- Institutional Diabetes Endocrinology Research Center (DERC) [DK32520]
- Cancer Center Core [CA34196]
- Beta Cell Biology Consortium
- Juvenile Diabetes Research Foundation, International
- Islet Isolation Center of the University of Pittsburgh
- NCRR
- NIDDK
- JDRE TE
- JD.RF M.K.
- American Diabetes Association
- NATIONAL CANCER INSTITUTE [P30CA034196] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P01AI046629] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK032520, P01DK053006] Funding Source: NIH RePORTER
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Our understanding of the basic biology of diabetes has been guided by observations made using animal models, particularly rodents. However, humans are not mice, and outcomes predicted by murine studies are not always representative of actual outcomes in the clinic. In particular, investigators studying diabetes have relied heavily on mouse and rat models of autoimmune type 1-like diabetes, and experimental results using these models have not been representative of many of the clinical trials in type 1 diabetes. In this article, we describe the availability of new models of humanized mice for the study of three areas of diabetes. These include the use of humanized mice for the study of (1) human islet stem and progenitor cells, (2) human islet allograft rejection, and (3) human immunity and autoimmunity. These humanized mouse models provide an important preclinical bridge between in vitro studies and rodent models and the translation of discoveries in these model systems to the clinic.
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