Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 242, Issue 1-2, Pages 9-14Publisher
ELSEVIER
DOI: 10.1016/j.jns.2005.11.020
Keywords
peripheral neuropathy; prediabetes; diabetes; metabolic syndrome; idiopathic
Categories
Funding
- NCRR NIH HHS [M01 RR0064] Funding Source: Medline
- NIDDK NIH HHS [R01 DK 064814] Funding Source: Medline
- NINDS NIH HHS [R01 NS 40458] Funding Source: Medline
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Peripheral neuropathy is a common problem encountered by neurologists and primary care physicians. While there are many causes for peripheral neuropathy, none can be identified in a large percentage of patients (idiopathic neuropathy). Despite its high prevalence, idiopathic neuropathy is poorly studied and understood. There is evolving evidence that impaired glucose tolerance (prediabetes) is associated with idiopathic neuropathy. Preliminary data from a multicenter study of diet and exercise in prediabetes (the Impaired Glucose Tolerance Neuropathy Study) suggests a diet and exercise counseling regimen based on the Diabetes Prevention Program results in improved metabolic measures and small fiber function. Prediabetes is part of the Metabolic Syndrome, which also includes hypertension, hyperlipidemia and obesity. Individual aspects of the Metabolic Syndrome influence risk and progression of diabetic neuropathy and may play a causative role in neuropathy both for those with prediabetes, and those with otherwise idiopathic neuropathy. Thus, a multifactorial treatment approach to individual components of Metabolic Syndrome may slow prediabetic neuropathy progression or result in improvement. (c) 2005 Elsevier B.V. All rights reserved.
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