4.8 Article

Sulfoximines as ligands in copper-catalyzed asymmetric vinylogous Mukaiyama-type aldol reactions

Journal

ORGANIC LETTERS
Volume 8, Issue 6, Pages 1209-1211

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AMER CHEMICAL SOC
DOI: 10.1021/ol060077d

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gamma,delta-Unsaturated alpha-hydroxy diesters with quaternary centers have been obtained with up to 99% ee in high yields using catalysts prepared from copper(II) triflate and C-1-symmetric aminosulfoximines.

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