Journal
ORGANIC LETTERS
Volume 8, Issue 6, Pages 1065-1068Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol052987l
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- NIGMS NIH HHS [T32 GM008523] Funding Source: Medline
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Azinomycins have potential therapeutic value as antitumor agents; however, their biosynthesis is poorly understood. Here, we provide the first demonstration of a protein cell-free system capable of supporting complete in vitro biosynthesis of the antitumor agent azinomycin B. The cell-free system is utilized to probe the cofactor dependence and substrate requirements of the pathway en route to azinomycin.
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