4.8 Article

An improved asymmetric Reformatsky reaction mediated by (-)-N,N-dimethylaminoisoborneol

Journal

ORGANIC LETTERS
Volume 8, Issue 6, Pages 1125-1128

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol0531381

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(-)-N,N-Dimethylaminoisoborneol ((-)-DAIB) was found to be an excellent ligand for the enantioselective addition of Reformatsky reagents to aromatic and aliphatic aldehydes. Enantioselectivities up to 93% ee were obtained with sulfur-containing aldehydes.

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