Journal
SCIENCE
Volume 311, Issue 5767, Pages 1576-1580Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1121586
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Funding
- NCI NIH HHS [CA 21765] Funding Source: Medline
- NIAID NIH HHS [AI95357] Funding Source: Medline
- NIGMS NIH HHS [R01 GM061739, R01 GM069916] Funding Source: Medline
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The spread of H5N1 avian influenza viruses (AIVs) from China to Europe has raised global concern about their potential to infect humans and cause a pandemic. In spite of their substantial threat to human health, remarkably little AIV whole-genome information is available. We report here a preliminary analysis of the first large-scale sequencing of AIVs, including 2196 AIV genes and 169 complete genomes. We combine this new information with public AIV data to identify new gene alleles, persistent genotypes, compensatory mutations, and a potential virulence determinant.
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