Journal
SCIENCE
Volume 311, Issue 5767, Pages 1609-1612Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1121449
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Funding
- NCI NIH HHS [R01 CA098161-04, R01 CA098161-01A1, R01 CA098161-03, R01 CA098161, R01 CA098161-02] Funding Source: Medline
- NCRR NIH HHS [P41 RR011823-128171, P41 RR011823] Funding Source: Medline
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During development, cells monitor and adjust their rates of accumulation to produce organs of predetermined size. We show here that central nervous system-specific deletion of the essential adherens junction gene, alpha E-catenin, causes abnormal activation of the hedgehog pathway, resulting in shortening of the cell cycle, decreased apoptosis, and cortical hyperplasia. We propose that alpha E-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and that this connection may provide a negative feedback loop controlling the size of developing cerebral cortex.
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