4.4 Article

Methodology for the synthesis of 1,2-disubstituted arylnaphthalenes from α-tetralones

Journal

TETRAHEDRON
Volume 62, Issue 12, Pages 2831-2844

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2006.01.013

Keywords

Suzuki-Miyaura coupling reactions; aromatization; arylnaphthalenes; alpha-tetralone

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alpha-Tetralones were initially converted into 1-bromo-dihydronaphthalene-2-carbaldehydes and 1-bromo-naphthalene-2carbaldehydes. These precursors were then subjected to Suzuki coupling reactions to afford 1,2-disubstituted aryldihydronaphthalenes and 1,2-disubstituted arylnaphthalenes, respectively. The former products were oxidized with DDQ to give 1,2-disubstituted arylnaphthalenes. (c) 2006 Elsevier Ltd. All rights reserved.

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