Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 203, Issue 3, Pages 505-511Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20050783
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Funding
- NIAID NIH HHS [AI55037, R21 AI055037, AI41647, R01 AI055037, R01 AI041647, R56 AI041647] Funding Source: Medline
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Regulatory T (T reg) cells exert powerful down-modulatory effects on immune responses, but it is not known how they act in vivo. Using intravital two-photon laser scanning microscopy we determined that, in the absence of T reg cells, the locomotion of autoantigen-specific T cells inside lymph nodes is decreased, and the contacts between T cells and antigen-loaded dendritic cells (DCs) are of longer duration. Thus, T reg cells can exert an early effect on immune responses by attenuating the establishment of stable contacts during priming of naive T cells by DCs.
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