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Interleukin-10 and chronic liver disease

Journal

WORLD JOURNAL OF GASTROENTEROLOGY
Volume 12, Issue 11, Pages 1681-1685

Publisher

BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v12.i11.1681

Keywords

interleukin (IL)-10; cytokine; chronic liver diseases; polymorphisms

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Interleukin (IL)-10 is an important immunoregulatory cytokine produced by many cell populations. Numerous investigations suggest that IL-10 plays a major role in chronic liver diseases. IL-10 gene polymorphisms are possibly associated with liver disease susceptibility or severity. Recombinant human IL-10 has been produced and is currently tested in clinical trials. These trials may give new insights into the immunobiology of IL-10 and suggest that the IL-10/IL-10 receptor system may become a new therapeutic target. (c) 2006 The WJG Press. All rights reserved.

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