Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 12, Pages 4723-4728Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0506806103
Keywords
Caenorhabditis elegans; optimal placement
Categories
Funding
- NCRR NIH HHS [R24 RR012596, RR 12596] Funding Source: Medline
- NIH HHS [R24 OD010943] Funding Source: Medline
- NIMH NIH HHS [MH 68938] Funding Source: Medline
Ask authors/readers for more resources
We pursue the hypothesis that neuronal placement in animals minimizes wiring costs forgiven functional constraints, as specified by synaptic connectivity. Using a newly compiled version of the Caenorhabditis elegans wiring diagram, we solve for the optimal layout of 279 nonpharyngeal neurons. In the optimal layout, most neurons are located close to their actual positions, suggesting that wiring minimization is an important factor. Yet some neurons exhibit strong deviations from optimal position. We propose that biological factors relating to axonal guidance and command neuron functions contribute to these deviations. We capture these factors by proposing a modified wiring cost function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available