Journal
NATURE
Volume 440, Issue 7083, Pages 470-476Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature04711
Keywords
-
Categories
Ask authors/readers for more resources
In responding to cytoplasmic nucleotide levels, ATP-sensitive potassium (K-ATP) channel activity provides a unique link between cellular energetics and electrical excitability. Over the past ten years, a steady drumbeat of crystallographic and electrophysiological studies has led to detailed structural and kinetic models that define the molecular basis of channel activity. In parallel, the uncovering of disease-causing mutations of K-ATP has led to an explanation of the molecular basis of disease and, in turn, to a better understanding of the structural basis of channel function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available