Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 27, Issue 6, Pages 441-446Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.200500778
Keywords
biomaterials; calcium phosphate; liposome; nanoparticles; polymer nanogel
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We report novel organic-inorganic hybrid nanomaterials that consist of polymer hydrogel nanoparticles (nanogels) and calcium phosphate. Hybrid nanoparticles that measure ca. 40 nm are synthesized from a dilute solution of hydroxyapatite using nanogels as templates for calcium phosphate mineralization. These nanoparticles show a narrow size distribution and high colloidal stability. Nanogel-adsorbed liposomes act as templates for hierarchical hybrid nanostructures. These nanohybrids can potentially be used as biocompatible drug carriers with controlled-release properties.
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