Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 341, Issue 4, Pages 1022-1028Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2006.01.062
Keywords
AQP1; water transport; C-fibers; pain
Categories
Funding
- NEI NIH HHS [EY 13574] Funding Source: Medline
- NHLBI NIH HHS [HL 59198] Funding Source: Medline
- NIBIB NIH HHS [EB 00415] Funding Source: Medline
- NIDDK NIH HHS [DK 35124] Funding Source: Medline
- NINDS NIH HHS [NS 050173] Funding Source: Medline
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Aquaporin-1 (AQP1), a membrane water channel, is expressed in choroid plexus where it contributes to cerebrospinal fluid production. Here, we show that AQP1 is also expressed in the dorsal horn of the spinal cord and the trigeminal nucleus caudalis, regions that process pain information. Within the dorsal root and trigeminal sensory ganglia, AQP1 is concentrated in small diameter cell bodies, most of which give rise to unmyelinated C-fibers. To study the role of AQP1 in pain signaling, we compared acute pain responses in wild-type mice and in mice lacking AQP1. AQP1(-/-) mice had reduced responsiveness to thermal and capsaicin chemical stimuli, but not to mechanical stimuli or formalin. These results provide evidence for AQP1 expression in nociceptive neurons and suggest that AQP1 may play a role in pain signal transduction. (c) 2006 Elsevier Inc. All rights reserved.
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