Journal
SCIENCE
Volume 311, Issue 5768, Pages 1775-1778Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1124004
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- NCI NIH HHS [T32 CA09382] Funding Source: Medline
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A cure for type 1 diabetes will probably require the provision or elicitation of new pancreatic islet beta cells as welt as the reestablishment of immunological tolerance. A 2003 study. reported achievement of both advances in the NOD mouse model by coupling injection of Freund's complete adjuvant with infusion of allogeneic spleen cells. it was concluded that the adjuvant eliminated anti-islet autoimmunity and the donor splenocytes differentiated into insulin-producing (presumably beta) cells, culminating in islet regeneration. Here, we provide data indicating that the recovered islets were all of host origin, reflecting that the diabetic NOD mice actually retain substantial beta cell mass, which can be rejuvenated/regenerated to reverse disease upon adjuvant-dependent dampening of autoimmunity.
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