The relationship between the preoperative systemic inflammatory response and cancer-specific survival in patients undergoing potentially curative resection for renal clear cell cancer

The relationship between tumour stage, grade ( Fuhrman), performance status ( ECOG), a combined score ( UCLA Integrated Staging System, UISS), systemic inflammatory response ( elevated C- reactive protein concentration), and cancer- specific survival was examined in patients undergoing potentially curative resection for renal clear cell cancer ( n = 100). On univariate survival analysis, sex ( P = 0.050), tumour stage ( P = 0.001), Fuhrman grade ( P < 0.001), UISS ( P < 0.001), C- reactive protein ( P = 0.002) were significant predictors of survival. On multivariate analysis with sex, UISS and C- reactive protein entered as covariates, only UISS ( HR 2.70, 95% CI 1.00 - 7.30, P = 0.050) and C- reactive protein ( HR 4.00, 95% CI 1.21 - 13.31, P = 0.024) were significant independent predictors of survival. The presence of a preoperative systemic inflammatory response predicts poor cancer- specific survival in patients who have undergone potentially curative resection for renal clear cell cancer.