Journal
BRITISH JOURNAL OF CANCER
Volume 94, Issue 6, Pages 828-834Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6603029
Keywords
breast cancer; chemotherapy; endocrine treatment; cognitive dysfunction
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The neuropsychological performance of 85 women with early stage breast cancer scheduled for chemotherapy, 43 women scheduled for endocrine therapy and/ or radiotherapy and 49 healthy control subjects was assessed at baseline ( T1), postchemotherapy ( or 6 months) ( T2) and at 18 months ( T3). Repeated measures analysis found no significant interactions or main effect of group after controlling for age and intelligence. Using a calculation to examine performance at an individual level, reliable decline on multiple tasks was seen in 20% of chemotherapy patients, 26% of nonchemotherapy patients and 18% of controls at T2 ( 18%, 14 and 11%, respectively, at T3). Patients who had experienced a treatment- induced menopause were more likely to show reliable decline on multiple measures at T2 ( OR= 2.6, 95% confidence interval ( CI) 0.823 - 8.266 P= 0.086). Psychological distress, quality of life measures and self- reported cognitive failures did not impact on objective tests of cognitive function, but were significantly associated with each other. The results show that a few women experienced objective measurable change in their concentration and memory following standard adjuvant therapy, but the majority were either unaffected or even improve over time.
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