Journal
JOURNAL OF NEUROSCIENCE
Volume 26, Issue 13, Pages 3584-3588Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.5146-05.2006
Keywords
dorsal striatum; caudate-putamen; cocaine; self-administration; reinstatement; extinction; abstinence
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Funding
- NIDA NIH HHS [DA15369, R01 DA017673, DA17673, DA10462] Funding Source: Medline
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Cue-induced reinstatement of extinguished drug seeking is a preclinical model of relapse. However, relapse typically occurs after abstinence rather than explicit extinction training. We show that inactivation of the dorsolateral caudate-putamen, but not other structures previously implicated in reinstatement, attenuates cocaine seeking after abstinence. This suggests that there is limited overlap in the substrates of cocaine seeking after abstinence versus extinction, and that habit learning exerts greater control over drug seeking than regions implicated in stimulus-reward associations.
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