Journal
ORGANIC LETTERS
Volume 8, Issue 7, Pages 1507-1510Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol060233g
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- NCI NIH HHS [CA31841] Funding Source: Medline
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A step-economical synthesis of 11-desmethyllaulimalide (2) is reported. This simplified analogue is available through an improved second-generation synthetic approach to the laulimalides, in a shorter step count and from much less expensive starting material than the parent compound. This new lead retains the anticancer function of laulimalide.
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