Journal
ORGANIC LETTERS
Volume 8, Issue 7, Pages 1283-1286Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol052948+
Keywords
-
Categories
Funding
- NIGMS NIH HHS [R01 GM050151-13, R01 GM050151, GM50151] Funding Source: Medline
Ask authors/readers for more resources
The synthesis of (+)-Sch 642305 (1) has been completed in 17 steps in 1.6% overall yield. Transannular Michael reaction of 2b with NaH in THF provided cyclohexenone 23 stereospecifically. Heating 23 in TFA/CDCl3 provided a 3:1 equilibrium mixture of 23 and 25, which was hydrolyzed to give (+)-6-epi-Sch 642305 (24) and (+)-Sch 642305 (1), respectively.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available