Journal
ORGANIC LETTERS
Volume 8, Issue 7, Pages 1327-1330Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol0600584
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A series of new chiral C-3-symmetric tris(beta-hydroxy phosphoramide) ligands have been synthesized via the reaction of trisphosphoramide ester and Grignard reagents. The catalytic asymmetric borane reduction of ketones with these new C-3-symmetric chiral tris(beta-hydroxy phosphoramide)s was investigated. Structurally well-defined, recoverable ligand 1d is an efficient catalyst for the enantioselective borane reduction of both electron-deficient and electron-rich ketones, and high enantioselectivities were achieved (up to 98% ee).
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