Journal
BIOCHEMICAL PHARMACOLOGY
Volume 71, Issue 7, Pages 930-940Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2005.11.012
Keywords
antibiotic; beta-lactam; beta-lactamase; resistance; inhibitor; mechanism
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Microbial resistance necessitates the search for new targets and new antibiotics. However, it is likely that resistance problems will eventually threaten these new products and it may, therefore, be instructive to review the successful employment of P-lactam antibiotic/plactamase inhibitor combinations to combat penicillin resistance. These combination drugs have proven successful for more than two decades, with inhibitor resistance still being relatively rare. The p-lactamase inhibitors are mechanism-based irreversible inactivators. The ability of the inhibitors to avoid resistance may be due to the structural similarities between the substrate and inhibitor. (c) 2005 Elsevier Inc. All rights reserved.
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