Journal
SCIENCE
Volume 311, Issue 5769, Pages 1924-1927Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1122927
Keywords
-
Categories
Ask authors/readers for more resources
Interleukin-2 (IL-2), which is a growth factor for T lymphocytes, can also sometimes be inhibitory. Thus, the proliferation of CD8(+) T cells in vivo is increased after the injection of a monoclonal antibody that is specific for IL-2 (IL-2 mAb), perhaps reflecting the removal of IL-2-dependent CD4(+) T regulatory cells (T regs). Instead, we show here that IL-2 mAb augments the proliferation of CD8(+) cells in mice simply by increasing the biological activity of preexisting IL-2 through the formation of immune complexes. When coupled with recombinant IL-2, some IL-2/IL-2 mAb complexes cause massive (>100-fold) expansion of CD8(+) cells in vivo, whereas others selectively stimulate CD4(+) T regs. Thus, different cytokine-antibody complexes can be used to selectively boost or inhibit the immune response.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available