Journal
HORMONES AND BEHAVIOR
Volume 49, Issue 4, Pages 458-462Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yhbeh.2005.10.002
Keywords
lordosis; progesterone; delta opioid receptors; MAPK; PD98059; DPDPE; RU486
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Funding
- NICHD NIH HHS [R01 HD29856] Funding Source: Medline
- NIMH NIH HHS [R37 MH41414] Funding Source: Medline
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The present study investigated the role of the progestin receptor (PR) and the mitogen-activated protein kinase (MAPK) pathway in the facilitation of lordosis behavior by the delta opioid receptor agonist [D-Pen 2, D-Pen(5)] -enkephalin (DPDPE). Ovariectomized, estrogen-primed rats were treated with the PR antagonist RU486 or the MAPK inhibitor PD98059 prior to intraventricular (icv) infusion of DPDPE. Both RU486 and PD98059 blocked receptive and proceptive behaviors induced by DPDPE at 60 min, and RU486 continued to inhibit estrous behavior at 90 min. Because delta opioid receptors can activate the p42/44 MAPKs, extracellular signal regulated kinases (ERK), we determined the effects of DPDPE on ERK phosphorylation. Icv infusion of DPDPE increased the levels of phosphorylated ERK in the hypothalamus and preoptic area of female rats, assessed by immunoblotting. These results support the participation of the PR and the MAPK pathway in the facilitation of lordosis behavior by delta opioid receptors. (C) 2005 Elsevier Inc. All rights reserved.
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