Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 116, Issue 4, Pages 1052-1062Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI27352
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Funding
- NHLBI NIH HHS [HL64272, R01 HL064272, T32 HL007115, HL07115, P01 HL049373, HL49373] Funding Source: Medline
- NIDDK NIH HHS [R29 DK046900, R01 DK046900, DK46900, R56 DK046900] Funding Source: Medline
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Plasma HDL cholesterol levels are inversely related to risk for atherosclerosis. The ATP-binding cassette, subfamily A, member 1 (ABCA1) mediates the rate-controlling step in HDL particle formation, the assembly of free cholesterol and phospholipids with apoA-I. ABCA1 is expressed in many tissues; however, the physiological functions of ABCA1 in specific tissues and organs are still elusive. The liver is known to be the major source of plasma HDL, but it is likely that there are other important sites of HDL biogenesis. To assess the contribution of intestinal ABCA1 to plasma HDL levels in vivo, we generated mice that specifically lack ABCA1 in the intestine. Our results indicate that approximately 30% of the steady-state plasma HDL pool is contributed by intestinal ABCA1 in mice. In addition, our data suggest that HDL derived from intestinal ABCA1 is secreted directly into the circulation and that HDL in lymph is predominantly derived from the plasma compartment. These data establish a critical role for intestinal ABCA1 in plasma HDL biogenesis in vivo.
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