Journal
NANO LETTERS
Volume 6, Issue 4, Pages 669-676Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl052405t
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Funding
- NCI NIH HHS [P50 CA114747, R24 CA93862, 1U54CA119367-01, R21 CA102123] Funding Source: Medline
- NIBIB NIH HHS [R21 EB001785] Funding Source: Medline
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We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered OD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.
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