Journal
NATURE GENETICS
Volume 38, Issue 4, Pages 418-420Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng1761
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It is an enigma how long-term selection in model organisms and agricultural species can lead to marked phenotypic changes without exhausting genetic variation for the selected trait. Here, we show that the genetic architecture of an apparently major locus for growth in chicken dissects into a genetic network of four interacting loci. The interactions in this radial network mediate a considerably larger selection response than predicted by a single-locus model.
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