Study of inclusion complex of β-cyclodextrin and nitrobenzene

P-cyclodextrin can react with nitrobenzene to form an inclusion complex which is characterized by H-1 NMR and powder X-ray diffractometry. The ratio of P-CD to NB in inclusion complex is deter-mined as 1:1. At 25 degrees C, the dissociated constant, K-D, of the inclusion complex is measured as 6.5 x 10(-3) M in neutral solution (pH = 7.0), but in alkali (pH = 13.5), K-D is 3.2 x 10(-2) M which is much larger than that measured in neutral. (c) 2005 Elsevier Ltd. All rights reserved.