Journal
JOURNAL OF NEUROVIROLOGY
Volume 12, Issue 2, Pages 146-152Publisher
SPRINGER
DOI: 10.1080/13550280600748946
Keywords
astrocyte; HIV-1; HIVD; HIVE; macrophage; provirus
Categories
Funding
- NIAID NIH HHS [R21-AI054207] Funding Source: Medline
- NIDA NIH HHS [K08 DA016160, K08 DA016160-04, K08-DA16160] Funding Source: Medline
- NINDS NIH HHS [NS049465, R01-NS37277, NS44807] Funding Source: Medline
Ask authors/readers for more resources
The importance of astrocytes as a reservoir of human immunodeficiency virus type 1 (HIV-1) in the brain remains elusive. By combining immunohistochemistry, laser capture microdissection, and triple-nested Alu -PCR, we demonstrate integrated HIV-1 in astrocytes and macrophages isolated directly from autopsy brain tissues of HIV-1-infected subjects. The ability of HIV-1 to integrate in terminally differentiated astrocytes suggests a permanent reservoir of provirus in brain that will impact the development and likely success of strategies aimed at eradicating HIV-1.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available