Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 296, Issue 1, Pages 324-331Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2005.08.047
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In this work, bovine hemoglobin (Hb) has been Studied mainly by the fluorescence method. pH has been found to exert a profound effect on Hb structure. This has been confirmed by fluorescence and circular dichroism (CD) studies. The pH-induced change in quaternary structure of Hb indirectly affects its secondary structure. This in turn affects ligand binding to Hb at various pH. The binding of two amphiphiles, a bile salt and a surfactant, have been investigated. The pH-induced structural modification of Hb has been confirmed by studies with the well-known denaturant urea and the polarity probe ANS, which has been used Lis an extrinsic fluorophore. (c) 2005 Published by Elsevier Inc.
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