Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 7, Issue 4, Pages 296-302Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1855
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Funding
- NICHD NIH HHS [R37 HD021502, R37 HD021502-20] Funding Source: Medline
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In 1924, Spemann and Mangold demonstrated the induction of Siamese twins in transplantation experiments with salamander eggs. Recent work in amphibian embryos has followed their lead and uncovered that cells in signalling centres that are located at the dorsal and ventral poles of the gastrula embryo communicate with each other through a network of secreted growth-factor antagonists, a protease that degrades them, a protease inhibitor and bone-morphogenic-protein signals.
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