Journal
JOURNAL OF SEPARATION SCIENCE
Volume 29, Issue 6, Pages 762-769Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.200500372
Keywords
chiral separations; chiralpak IA; chiralpak IB; immobilization; polysaccharide CSP
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Immobilized polysaccharide-based chiral stationary phases (CSPs) are gaining importance in the resolution of racemic compounds due to their stable nature on working with normal solvents and those prohibited for use with coated phases (tetrahydrofuran, chloroform, dichloromethane, acetone, 1,4-dioxane, ethyl acetate, and certain other ethers). This review discusses the use of immobilized polysaccharide CSPs in the chiral resolution of various racemates by liquid chromatography. The discussion includes immobilization methodologies, enantioselectivities, efficiencies, and a comparison of chiral recognition capabilities of coated vs. immobilized CSPs. Some applications of immobilized CSPs to the chiral resolution of racemic compounds are also presented.
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