Journal
BLOOD
Volume 107, Issue 7, Pages 2774-2776Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2005-08-3210
Keywords
-
Categories
Funding
- NCI NIH HHS [P01-CA80124, R01-CA115767, R01-CA96915, P01 CA080124] Funding Source: Medline
Ask authors/readers for more resources
Recent studies have demonstrated that the cellular contribution of the bone marrow to tumor neovascularization is highly complex. In this context, the extent to which bone marrow-derived cells incorporate as bona fide endothelial (nonhematopoietic) cells into perfused tumor vessels, or any new vessels formed postnatally (vasculogenesis), is unclear. To this end, we developed models to characterize local vessel-derived and bone marrow-derived endothelial cells (BMD-ECs). Then, we characterized the BMD-ECs based on a set of endothelial markers and morphology. Finally, we quantified their contribution to perfused blood vessels in tumors using transplanted as well as spontaneous primary and metastatic tumor models. We demonstrate that BMD-ECs incorporate in perfused tumor vessels, and that this contribution varies with organ site and mouse strain.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available