Journal
NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM
Volume 2, Issue 4, Pages 220-230Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncpendmet0159
Keywords
growth factors; oncogenes; pituitary; tumor-suppressor genes; tumors
Categories
Ask authors/readers for more resources
Pituitary tumors exhibit a spectrum of biology, with variable growth and hormonal behaviors. They therefore provide an opportunity to examine pathogenetic mechanisms that underlie the neoplastic process. These include alterations in hormone regulation, growth-factor stimulation, cell-cycle control and cell-stromal interactions that result from genetic mutations or epigenetic disruption of gene expression. Mouse models have validated the roles of these alterations, which can be targets for the development of therapies that can manage these lesions. These therapies are increasingly recognized as critical for quality of life.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available