Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 16, Issue 2, Pages 172-177Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2006.02.003
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With the progression of structural genomics projects, comparative modeling remains an increasingly important method of choice. It helps to bridge the gap between the available sequence and structure information by providing reliable and accurate protein models. Comparative modeling based on more than 30% sequence identity is now approaching its natural template-based limits and further improvements require the development of effective refinement techniques capable of driving models toward native structure. For difficult targets, for which the most significant progress in recent years has been observed, optimal template selection and alignment accuracy are still the major problems.
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