Journal
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Volume 57, Issue 4, Pages 720-723Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jac/dkl007
Keywords
bacterial meningitis; treatment; S. aureus; cyclic lipopeptide
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Objectives: To test the efficacy of daptomycin, a cyclic lipopeptide antibiotic, against a methicillin-susceptible Staphylococcus aureus strain in experimental rabbit meningitis and to determine its penetration into non-inflamed and inflamed meninges Results: Over a treatment period of 8 h, daptomycin (15 mg/kg) was significantly superior to the comparator regimen vancomycin (-4.54 +/- 1.12 log(10)/mL for daptomycin versus -3.43 +/- 1.17 log(10)/mL for vancomycin). Daptomycin managed to sterilize 6 out of 10 CSFs compared with 4 out of 10 for vancomycin. The penetration of daptomycin into inflamed meninges was similar to 5% and similar to 2% into non-inflamed meninges. Conclusions: The superior bactericidal activity of daptomycin was confirmed in vivo and in time-killing assays in vitro.
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