Journal
JOURNAL OF VIROLOGY
Volume 80, Issue 7, Pages 3684-3691Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.80.7.3684-3691.2006
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Funding
- NIAID NIH HHS [AI054207-01-A1, R21 AI054207] Funding Source: Medline
- NINDS NIH HHS [R01 NS037277, NS37277] Funding Source: Medline
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We characterized human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins (Env) isolated from two HIV-1-infected CCR5 Delta 32 homozygotes. Envs from both subjects used CCR5 and CXCR4 for entry into transfected cells. Most R5X4 Envs were lymphocyte-tropic and used CXCR4 exclusively for entry into peripheral blood mononuclear cells (PBMC), but a subset was dually lymphocyte- and macrophage-tropic and used either CCR5 or CXCR4 for entry into PBMC and monocyte-derived macrophages. The persistence of CCR5-using HIV-1 in two CCR5 Delta 32 homozygotes suggests the conserved CCR5 binding domain of Env is highly stable and provides new mechanistic insights important for HIV-1 transmission and persistence.
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