Journal
MOVEMENT DISORDERS
Volume 21, Issue 4, Pages 534-539Publisher
WILEY
DOI: 10.1002/mds.20752
Keywords
Parkinson's disease; alpha-synuclein; Rep1; polymorphism; association study
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The alpha-synuclein Rep1 polymorphism was studied in patients and controls in an ethnic Greek population. There was an association of allele 2 with risk of Parkinson's disease (PD: adjusted odd ratio = 3.25; 95% Cl = 1.80-5.87). Survival analyses (Cox proportional hazards models) were employed to explore the influence of genotypes on age at onset of PD. Age at onset of carriers of at least one Rep I allele 2 was earlier (3.6 years) compared to noncarriers (adjusted hazard ratio = 2.21 95% CI = 1.58-3.10). Kaplan-Meier analysis also Supported a dosage effect of Rep1 allele 2 on age at onset. For Rep1 allele 1. there was neither association with risk of PD nor influence on age at onset. This is the first stud showing an influence of Rep1 polymorphism on age at onset of PD. (C) 2005 Movement Disorder Society.
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