Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 6, Issue 4, Pages 697-702Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2005.10.003
Keywords
Phellinus linteus; metastasis; invasion; adhesion
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The acidic polysaccharide (PL) from Phellinus linteus is an immunostimulator that has therapeutic activity against cancers. Here, we show that PL markedly inhibits melanoma cell metastasis in mice, and report that PL directly inhibits cancer cell adhesion to and invasion through the extracellular matrix, but that it has no direct effect on cancer cell growth. In addition, we found that PL increased macrophage NO production. These results suggest that PL has two antimetastatic functions, i.e., it acts as an immunopotentiator and as a direct inhibitor of cancer cell adhesion. (c) 2005 Elsevier B.V All rights reserved.
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