Journal
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
Volume 131, Issue 4, Pages 838-842Publisher
MOSBY, INC
DOI: 10.1016/j.jtcvs.2005.11.028
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Objectives: Some investigators have reported long-term survival after surgical resection of a solitary non - small cell lung cancer recurrence in various sites. However, the role and indications of the second operation remain unclear. Methods: We reviewed 28 patients with a solitary recurrence after successful initial resection of primary non - small cell lung cancer who underwent resection of the recurrent lesion. The clinicopathologic factors associated with outcome were analyzed. Results: There were 17 men and 11 women. Recurrence resection was performed for the following sites: 16 in the lung, 5 in the brain, 2 in the adrenal gland, and 1 each in the chest wall, stomach, skin, pelvic lymph node, and malar bone. The median survival time was 25 months, and the 1-, 2-, and 5-year survival rates after recurrence were 89%, 59%, and 32%, respectively. Advanced p-stage ( p-stage II and III, n = 14) of the primary tumor was the significant negative prognostic factor. Patients with p-stage II or III had survival equivalent to that of those who had multiple recurrences or were unfit for further surgical intervention. Conclusions: Resection of a solitary non - small cell lung cancer recurrence might provide long-term survival in highly selected patients. However, surgical resection might be contraindicated if the primary tumor is stage II or III.
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