Journal
ANNALS OF SURGICAL ONCOLOGY
Volume 19, Issue 12, Pages 3856-3864Publisher
SPRINGER
DOI: 10.1245/s10434-012-2392-5
Keywords
-
Funding
- Chang Gung Memorial Hospital [CMRPG340381, CMRPG360701, CMRPG360851, CMRPG371511, CMRPG3A0281]
- National Science Council [NSC99-2314-B-182A-036-MY3]
- Department of Health, Department Executive Yuan, Taiwan [DOH99-TD-C-111-006]
Ask authors/readers for more resources
Squamous cell carcinoma antigen (SCC-Ag) level and C-reactive protein (CRP) have been shown to be associated with tumor invasion, lymph node metastasis, staging and survival in patients with oral squamous cell carcinoma (OSCC). The purpose of the present study was to analyze the relationship between preoperative levels of both SCC-Ag and CRP, with clinicopathologic factors and prognosis in OSCC patients. A retrospective study was performed on 142 OSCC patients between March 2008 and March 2011. Their serum SCC-Ag and CRP levels were measured preoperatively. SCC-Ag level of a parts per thousand yen2.0 ng/ml and CRP level a parts per thousand yen5.0 mg/L were significantly associated with pathologic tumor status (P < 0.001), pathologic nodal metastasis (P = 0.001), tumor depth (a parts per thousand yen10 mm vs. < 10 mm, P < 0.001), disease-free survival (P a parts per thousand currency sign 0.001) and overall survival (P a parts per thousand currency sign 0.001). The influence of SCC-Ag and CRP level on disease-free survival (hazard ratio 4.046, 95 % confidence interval 1.698-9.692) and overall survival (hazard ratio 3.655, 95 % confidence interval 1.464-9.130) still existed after adjusting for tumor status, lymph node metastasis and tumor cell differentiation. Concurrent high levels of both preoperative SCC-Ag and CRP levels act as a predictor for lymph node metastasis, advanced tumor stage and tumor recurrence. It therefore has significant potential as a biomarker for risk stratification in OSCC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available