4.2 Article

Efficient solvent-free synthesis of quinolines promoted by BiCl3

Journal

LETTERS IN ORGANIC CHEMISTRY
Volume 3, Issue 4, Pages 289-291

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157017806776114568

Keywords

quinoline; o-aminoaryl ketones; alpha-methylene ketones; Friedlander reaction; BiCl3; solvent-free

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Poly-substituted quinolines are readily prepared in excellent yields via a Friedlander reaction of o-aminoarylketone or o-aminoarylaldehyde with alpha-methylene ketones in the presence of BiCl3 under solvent-free and thermal heating conditions.

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