Journal
EPIGENETICS
Volume 1, Issue 2, Pages 63-66Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/epi.1.2.2767
Keywords
DNA methyltransferase; DNA methylation; Dnmt1; enzyme mechanism; enzyme kinetics; enzyme regulation; maintenance methylation; protein DNA interaction
Funding
- DFG
- BMBF
- NIH
Ask authors/readers for more resources
In this short review the enzymatic properties of Dnmt1 are summarized. Studies on the specificity of Dnmt1 have shown that it has 30-40 fold preference for hemimethylated target sites. It methylates hemimethylated DNA in a processive reaction, moving on the DNA in a random walk. Binding of DNA to allosteric site(s) in the N-terminal part of the enzyme can lead to stimulation and inhibition of its catalytic activity depending on the nature of the substrate and effector.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available