Journal
EXPERIMENTAL EYE RESEARCH
Volume 82, Issue 4, Pages 545-557Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2005.10.011
Keywords
glaucoma; Schlemm's canal; hydraulic conductivity
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Funding
- NEI NIH HHS [R01 EY009699, R01 EY009699-08, R01-EY09699] Funding Source: Medline
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The bulk of aqueous humour outflow resistance is generated in or near the inner wall endothelium of Schlemm's canal in normal eyes, and probably also in glaucomatous eyes. Fluid flow through this region is controlled by the location of the giant vacuoles and pores found in cells of the endothelium of Schlemm's canal, but the flow resistance itself is more likely generated either in the extracellular matrix of the juxtacanalicular connective tissue or the basement membrane of Schlemm's canal. Future studies utilizing in vitro perfusion studies of inner wall endothelial cells may give insights into the process by which vacuoles and pores form in this unique endothelium and why inner wall pore density is greatly reduced in glaucoma. (c) 2005 Elsevier Ltd. All rights reserved.
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