Journal
JOURNAL OF NEUROSCIENCE RESEARCH
Volume 83, Issue 5, Pages 711-730Publisher
WILEY
DOI: 10.1002/jnr.20767
Keywords
Toll-like receptor (TLR); pattern recognition receptor (PRR); pathogen-associated molecular pattern (PAMP); central nervous system
Categories
Funding
- NIMH NIH HHS [R01 MH065297, R01 MH065297-03, MH-65297, R01 MH065297-04] Funding Source: Medline
- NINDS NIH HHS [P30 NS047546, P30 NS047546-01A1, R01 NS040730-05, R01 NS040730, NS-40730, R01 NS040730-06, P30 NS047546-02] Funding Source: Medline
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Toll-like receptors (TLRs) are a family of pattern-recognition receptors expressed on cells of the innate immune system that allow for the recognition of conserved structural motifs on a wide array of pathogens, referred to as pathogen-associated molecular patterns, as well as some endogenous molecules. The recent emergence of studies examining TLRs in the central nervous system (CNS) indicates that these receptors not only play a role in innate immunity in response to infectious diseases but may also participate in CNS autoimmunity, neurodegeneration, and tissue injury. This review summarizes the experimental evidence demonstrating a role for TLRs in the context of CNS inflammation in both infectious and noninfectious conditions. (C) 2006 Wiley-Liss, Inc.
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