Journal
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
Volume 296, Issue 2-3, Pages 141-147Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.ijmm.2006.01.040
Keywords
peptide signal molecule; horizontal gene transfer; genetic regulation
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Funding
- NHLBI NIH HHS [HL51987, R01 HL051987, R01 HL051987-12] Funding Source: Medline
- NIAID NIH HHS [R01 AI058134] Funding Source: Medline
- NIGMS NIH HHS [T32 GM08347, GM49530, T32 GM008347, R01 GM049530, R01 GM049530-20] Funding Source: Medline
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Pheromone-inducible transfer of the plasmid pCF10 in Enterococcus faecalis is regulated using a complicated network of proteins and RNAs. The plasmid itself has been assembled from parts garnered from a variety of sources, and many aspects of the system resemble a biological kluge. Recently several new functions of various pCF10 gene products that participate in regulation of plasmid transfer have been identified. The results indicate that selective pressures controlling the evolution of the plasmid have produced a highly complex regulatory network with multiple biological functions that may serve well as a model for the evolution of biological complexity. (c) 2006 Elsevier GmbH. All rights reserved.
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