Journal
NANO LETTERS
Volume 6, Issue 4, Pages 779-782Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl0601076
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Funding
- NHGRI NIH HHS [R01 HG002647, R01 HG002647-04] Funding Source: Medline
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A rapid and low-cost method to sequence DNA would usher in a revolution in medicine. We propose and theoretically show the feasibility of a protocol for sequencing based on the distributions of transverse electrical currents of single-stranded DNA while it translocates through a nanopore. Our estimates, based on the statistics of these distributions, reveal that sequencing of an entire human genome could be done with very high accuracy in a matter of hours without parallelization, that is, orders of magnitude faster than present techniques. The practical implementation of our approach would represent a substantial advancement in our ability to study, predict, and cure diseases from the perspective of the genetic makeup of each individual.
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