Journal
BIOMACROMOLECULES
Volume 7, Issue 4, Pages 1179-1186Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm050995j
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Novel polymeric amphiphilic copolymers were synthesized using chondroitin sulfate (CS) as a hydrophilic segment and poly(L-lactide) (PLLA) as a hydrophobic segment. Micelles of those copolymers were formed in an aqueous phase and were characterized by H-1 NMR spectra, fluorescence techniques, dynamic light scattering (DLS), atomic force microscopy (AFM), and confocal microscopy. Their critical aggregation concentrations (CAC) are in the range of 0.0043-0.0091 mg/mL at 25 degrees C. The partition equilibrium constants, K-v, of the pyrene probe in the aqueous solution were from 3.65 x 10(5) to 1.41 x 10(6) at 25 degrees C. The mean diameters of the micelles were below 200 nm, and their sizes were narrowly distributed. The AFM images revealed that the self-aggreggates were spherical. Additionally, the CSn-PLLA micelles can efficiently transport within the cells via endocytosis as observed from confocal microscopy.
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