Journal
BIOMACROMOLECULES
Volume 7, Issue 4, Pages 1261-1265Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm050920f
Keywords
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Funding
- NCI NIH HHS [P50-CA86355, R01 CA99385] Funding Source: Medline
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Controlled delivery of drugs in response to environments has the potential of targeting therapies and personalized treatments. Here, we described self-assembled peptide sequences that release therapeutic payloads upon specific interaction with disease-associated proteases. The core peptide sequence consists of a protease cleavable region flanked by two self-assembly motifs. In aqueous solution, the peptides self-assemble as a gel scaffold. With treatment of the model preparations with the appropriate protease, the matrix can be degraded in a controlled fashion, where the degradation rate is fine-tuned by varying the peptide compositions. Protease-mediated drug release was demonstrated by enzymatic treatment of a model therapeutic peptide incorporated into the optimized matrix. Our results suggest that this type of material may have far-reaching applications for functionally targeted drug delivery.
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